Inhibitory Effects of Talipexole and Pramipexole on MPTP-InducedDopamine Reduction in the Striatum of C57BL/6N Mice

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Author(s)

Abstract

We have investigated the effects of two novel antiparkinsonian drugs, talipexole (Domin®)and pramipexole, on MPTP-induced dopamine (DA)reduction in the striatum of C57BL/6N mice in comparison with those of bromocriptine. Fifteen days after MPTP treatment (25 mg/kg, i.p., given daily for 5 days), the DA content in the striatum was decreased to 40-60010 of the control value. Among the three dopamine receptor agonists, talipexole and pramipexole (1 mg/kg, i.p., once a day for 20 days)more significantly suppressed the MPTP-induced DA reduction in the striatum than bromocriptine (10 mg/kg, i.p., once a day for 20 days). Talipexole did not influence [<SUP>3</SUP>H]MPP<SUP>+</SUP> uptake into striatal synaptosomes. These results suggest that talipexole and pramipexole have a protective effect against MPTP-induced DA reduction in the striatum of C57BL/6N mice.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 74(1), 51-57, 1997-05-01

    The Japanese Pharmacological Society

References:  31

Cited by:  5

Codes

  • NII Article ID (NAID)
    10008678379
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    4219982
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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