Effect of KW-5092, Novel Gastroprokinetic Agent, on the Peristalsis in the Isolated Guinea Pig Ileum

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Author(s)

Abstract

We examined the effect of KW-5092, a gastroprokinetic agent with acetylcholinesterase inhibitory and acetylcholine release facilitatory activities, on the peristalsis of isolated guinea pig ileum. KW-5092 (10<SUP>-9</SUP>-3 × 10<SUP>-6</SUP> M)increased the frequency of the peristaltic wave without changing its amplitude. Neostigmine increased the frequency at 10<SUP>-7</SUP> M, but domperidone (10<SUP>-8</SUP>-3 × 10<SUP>-6</SUP> M)had no effect on the peristalsis. The present results suggest that KW-5092 enhances the peristalsis via the inhibition of acetylcholinesterase, resulting in the intestinal propulsion.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 74(1), 91-94, 1997-05-01

    The Japanese Pharmacological Society

References:  12

Codes

  • NII Article ID (NAID)
    10008678539
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    00215198
  • NDL Article ID
    4219987
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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