Effect of KW-5092, Novel Gastroprokinetic Agent, on the Peristalsis in the Isolated Guinea Pig Ileum.

• Suzuki Mayumi

  Department of Pharmacology, Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.

• Kishibayashi Nobuyuki

  Department of Pharmacology, Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.

• Yokoyama Toshihide

  Department of Pharmacology, Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.

• Karasawa Akira

  Department of Pharmacology, Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.

書誌事項

タイトル別名

• Effect of KW-5092 Novel Gastroprokineti

抄録

We examined the effect of KW-5092, a gastroprokinetic agent with acetylcholinesterase inhibitory and acetylcholine release facilitatory activities, on the peristalsis of isolated guinea pig ileum. KW-5092 (10^-9-3 × 10^-6 M)increased the frequency of the peristaltic wave without changing its amplitude. Neostigmine increased the frequency at 10^-7 M, but domperidone (10^-8-3 × 10^-6 M)had no effect on the peristalsis. The present results suggest that KW-5092 enhances the peristalsis via the inhibition of acetylcholinesterase, resulting in the intestinal propulsion.

収録刊行物

• Jpn.J.Pharmacol.

  Jpn.J.Pharmacol. 74 (1), 91-94, 1997

  公益社団法人 日本薬理学会

キーワード

• Peristalsis
• Ileum
• Acetylcholine

詳細情報

• CRID: 1390282679261198592
• NII論文ID: 10008678539
• NII書誌ID: AA00691188
• DOI: 10.1254/jjp.74.91
• COI: 1:CAS:528:DyaK2sXjs1Gitbg%3D
• ISSN: 13473506
• ISSN: 00215198
• NDL書誌ID: 4219987
• PubMed: 9195302
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4219987
• Web Site: https://search.jamas.or.jp/link/ui/1997222940
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可