Suppression of Ischemic Edema in Mice by Manganese-Hyaluronate Conjugate

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Author(s)

    • Andoh Mariko ANDOH Mariko
    • Toin Human Science and Technology Center, Department of Materials Science and Technology,Toin University of Yokohama
    • KODERAI Yoh
    • Toin Human Science and Technology Center, Department of Materials Science and Technology,Toin University of Yokohama
    • NISHIMURA Hiroyuki
    • Toin Human Science and Technology Center, Department of Materials Science and Technology,Toin University of Yokohama
    • HIROTO Misao
    • Toin Human Science and Technology Center, Department of Materials Science and Technology,Toin University of Yokohama
    • MATSUSHIMA Ayako
    • Toin Human Science and Technology Center, Department of Materials Science and Technology,Toin University of Yokohama
    • AOYAMA Masaaki
    • Institutefor Life Support Technology, Yamagata Technopolis Foundation
    • INADA Yuji
    • Toin Human Science and Technology Center, Department of Materials Science and Technology,Toin University of Yokohama

Abstract

Manganese-hyaluronate conjugate (Mn-HA) was synthesized from a diethylenetriaminepentaacetic acid derivative of hyaluronic acid and manganese ion. The conjugate markedly scavenged superoxide anion in vitro and exhibited much higher anti-inflammatory activity than superoxide dismutase in suppressing paw edema in mice when intravenously injected 30 min before the initiation of ischemia.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 74(1), 117-120, 1997-05-01

    The Japanese Pharmacological Society

References:  15

Codes

  • NII Article ID (NAID)
    10008678623
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    00215198
  • NDL Article ID
    4219993
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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