Structure and Function of Inositol 1 ,4,5 : Trisphosphate Receptor

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Author(s)

Abstract

Generation of intracellular Ca<SUP>2+</SUP> signals in response to Ca<SUP>2+</SUP> -mobilizing stimuli is a critical event in the control of many cellular processes. Inositol 1, 4, 5-trisphosphate (IP<SUB>3</SUB>)represents a dominant second messenger subserving the release of Ca<SUP>2+</SUP> from intracellular store sites. The protein on the surface of which the IP<SUB>3</SUB> receptor is located comprises an IP<SUB>3</SUB>-gated Ca<SUP>2+</SUP> channel, and binding of IP<SUB>3</SUB> to this receptor triggers the release of Ca<SUP>2+</SUP> through this channel. The receptor for IP<SUB>3</SUB> displays a close resemblance to the ryanodine receptor, another intracellular Ca<SUP>2+</SUP> channel, in many molecular and physiological properties. Many lines of evidence strongly suggest the central role that the IP3 receptor plays in the conversion of numerous external stimuli to intracellular Ca<SUP>2+</SUP> signals characterized by complex spatiotemporal patterns such as Ca<SUP>2+</SUP> waves and oscillations. In this review, we shall summarize our current knowledge of the structure and function of the IP<SUB>3</SUB> receptor in order to understand the way how the activity of this important receptor is regulated to accomodate itself to the generation of diverse intracellular Ca<SUP>2+</SUP> signals.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 74(2), 125-137, 1997-06-01

    The Japanese Pharmacological Society

References:  119

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Cited by:  1

Codes

  • NII Article ID (NAID)
    10008678647
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    4260341
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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