The Novel Anti-Rheumatic Drug TA-383 Has a Macrophage Migration Enhancing Activity.
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- Ueno Makoto
- Lead Generation Research Laboratory, Tanabe Seiyaku Co., Ltd.
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- Sugita Takahisa
- Lead Generation Research Laboratory, Tanabe Seiyaku Co., Ltd.
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- Murakami Takanori
- Lead Generation Research Laboratory, Tanabe Seiyaku Co., Ltd.
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- Takata Isao
- Lead Generation Research Laboratory, Tanabe Seiyaku Co., Ltd.
Bibliographic Information
- Other Title
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- Novel Anti-Rheumatic Drug TA-383 Has a
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Abstract
We have investigated the effect of a novel anti-rheumatic drug, cis-2-(4-chlorophenyl)-4, 5-diphenyl-2-imidazoline hydrochloride (TA-383), on macrophages. TA-383 (≥10-9 M)significantly stimulated rabbit alveolar macrophage (AM)migration, and its migration-stimulatory activity was more potent than those of L-fucose (5 × 10-3 M), lobenzarit disodium, bucillamine (SA-96)and salazosulfapyridine. In addition, TA-383 enhanced the production and/or release of macrophage migration enhancement factor by rabbit spleen cells. In vivo, TA-383 (0.4 mg/kg, p.o.)has suppressive effects on picryl chloride-induced delayed type hypersensitivity and type II collagen-induced arthritis in mice. These results suggest that the anti-rheumatic activity of TA-383 may be exerted through the dispersion of macrophages from inflammatory sites.
Journal
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- The Japanese Journal of Pharmacology
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The Japanese Journal of Pharmacology 74 (2), 221-224, 1997
The Japanese Pharmacological Society
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Details 詳細情報について
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- CRID
- 1390001204286271360
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- NII Article ID
- 10008679088
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- NII Book ID
- AA00691188
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- COI
- 1:CAS:528:DyaK2sXktVOlsLo%3D
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- ISSN
- 13473506
- 00215198
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- NDL BIB ID
- 4260354
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- PubMed
- 9243333
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed
