The Novel Anti : Rheumatic Drug TA : 383 Has a Macrophage Migration Enhancing Activity

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Author(s)

Abstract

We have investigated the effect of a novel anti-rheumatic drug, <I>cis</I>-2-(4-chlorophenyl)-4, 5-diphenyl-2-imidazoline hydrochloride (TA-383), on macrophages. TA-383 (≥10<SUP>-9</SUP> M)significantly stimulated rabbit alveolar macrophage (AM)migration, and its migration-stimulatory activity was more potent than those of L-fucose (5 × 10<SUP>-3</SUP> M), lobenzarit disodium, bucillamine (SA-96)and salazosulfapyridine. In addition, TA-383 enhanced the production and/or release of macrophage migration enhancement factor by rabbit spleen cells. In vivo, TA-383 (0.4 mg/kg, p.o.)has suppressive effects on picryl chloride-induced delayed type hypersensitivity and type II collagen-induced arthritis in mice. These results suggest that the anti-rheumatic activity of TA-383 may be exerted through the dispersion of macrophages from inflammatory sites.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 74(2), 221-224, 1997-06-01

    The Japanese Pharmacological Society

References:  15

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008679088
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    4260354
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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