Effect of Long-Term Administration of Berberine on Scopolamine: Induced Amnesia in Rats

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Author(s)

Abstract

The effect of berberine (BER)on scopolamine (SCOP)-induced amnesia was investigated in a step-through passive avoidance task in rats. It was observed that BER at the doses of 0.1 and 0.5 g/kg after 7-day or 14-day administration significantly improved SCOP-induced amnesia. The anti-amnesic effect of BER after 14-day administration on the SCOP-induced amnesia was significantly augmented by physostigmine or neostigmine, and completely reversed by scopolamine <I>N</I>-methylbromide. These results suggest that the antiamnesic effect of BER after 14-day administration may be related to the increase in the peripheral and central cholinergic neuronal system activity.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 74(3), 261-266, 1997-07-01

    The Japanese Pharmacological Society

References:  29

Cited by:  2

Codes

  • NII Article ID (NAID)
    10008679281
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    4260358
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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