Cimetidine Inhibits the Induction of Long-Term Potentiation in the Dentate Gyrus of Rats In Vivo

Access this Article

Author(s)

Abstract

We investigated the effect of cimetidine, a clinically used H<SUB>2</SUB>-receptor antagonist, on the induction of long-term potentiation (LTP)in the dentate gyrus of anesthetized rats. Intracerebroventricular injection of cimetidine (50-100 nmol)inhibited the induction of LTP in a dose-dependent manner. The inhibitory effect of cimetidine was not mimicked by other H<SUB>2</SUB>-receptor antagonists (ranitidine, famotidine)or the H<SUB>1</SUB>-receptor antagonist diphenhydramine or the H<SUB>3</SUB>-receptor antagonist thioperamide. These results suggest that cimetidine inhibits hippocampal synaptic plasticity by a novel brain mechanism unrelated to H<SUB>1</SUB>, H<SUB>2</SUB> or H<SUB>3</SUB> receptors.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 74(3), 281-283, 1997-07-01

    The Japanese Pharmacological Society

References:  15

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008679372
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    4260361
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
Page Top