Immunopharmacological Studies on Collagen-Induced Arthritis in Dark Agouti (DA) Rats

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Author(s)

Abstract

Dark Agouti (DA)and Lewis rat strains were tested for susceptibility to collagen-induced arthritis (CIA)and for development of cellular and humoral immune responses to type II collagen (CII). All of the DA rats developed arthritis following a single intradermal injection of more than 20 μg of CII (130-150 μg/kg rat weight)and showed a swelling rate of more than 100% in the hind paws. The swelling rate showed little deviation among the animals. There was a strong correlation between the severity of the arthritis and the strength of the immune response to CII in DA rats with CIA. Following immunization with even 800 μg of CII (3.8-4.2 mg/kg rat weight), Lewis rats showed a maximum rate of hind paw swelling of only 45%. In the pharmacological studies, prednisolone, indomethacin, FK-506 and mizoribine all suppressed arthritis in DA rats. These findings suggest that DA rats are more susceptible to CIA than Lewis rats and that CIA in DA rats as well as in Lewis rats is serviceable as an experimental animal model of rheumatoid arthritis.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 74(4), 313-322, 1997-08-01

    The Japanese Pharmacological Society

References:  35

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008679482
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    4287827
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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