Antiepileptic Effects of 20-Hydroxyecdysone on Convulsive Seizures in Spontaneously Epileptic Rats

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Author(s)

Abstract

We examined the effect of 20-hydroxyecdysone (20-HE), a neurosteroid found in insects that is involved in their developmental process, on both tonic convulsion and absence-like seizure in spontaneously epileptic rat (SER). When 20-HE was given orally to SER at 25 200 mg/kg, significant decreases of the tonic convulsion were observed with 100 and 200 mg/kg. Pretreatment of the animal with bicuculline (1 mg/kg, i.p.)antagonized the inhibitory effects of 20-HE. However, absence-like seizures were not affected by 20-HE. These findings indicate that 20-HE produces antiepileptic effects on tonic convulsion by acting on the modulatory site of GABA<SUB>A</SUB> receptors.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 74(4), 331-335, 1997-08-01

    The Japanese Pharmacological Society

References:  14

Cited by:  3

Codes

  • NII Article ID (NAID)
    10008679542
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    4287829
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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