Activin Selectively Abolishes Hippocampal Long-Term Potentiation Induced by Weak Tetanic Stimulation In Vivo

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Author(s)

Abstract

Although modulation of hippocampal synaptic plasticity by neurotrophins or growth factors has recently become an extensively investigated subject, there are no reports arguing for the contribution of the transforming growth factor (TGF)-β superfamily. In the present study, we examined the effect of activin, a member of the TGF-β superfamily, on long-term potentiation (LTP) of the dentate gyrus in anesthetized rats. Activin significantly impaired the formation of LTP induced by tetanic stimulation (60 Hz for 0.27 sec), but not that by strong tetanic stimulation (60 Hz for 0.5 sec). These results suggest that activin selectively blocks the induction of LTP evoked by threshold tetanic stimulation.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 75(1), 87-89, 1997-09-01

    The Japanese Pharmacological Society

References:  15

Codes

  • NII Article ID (NAID)
    10008679829
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    00215198
  • NDL Article ID
    4307648
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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