Effect of Lecithinized-Superoxide Dismutase on the Interstitial Pneumonia Model Induced by Bleomycin in Mice

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Author(s)

Abstract

Superoxide anion (0<SUB>2</SUB><SUP>-</SUP>) acts as an exacerbation factor in interstitial pneumonia. Lecithinized-superoxide dismutase (PC-SOD), which is synthesized with a lecithin derivative bound covalently to recombinant human Cu, Zn-SOD, has a longer half-life in plasma and higher affinity to cell membranes than unmodified SOD. The effect of PC-SOD was evaluated using the bleomycin-induced interstitial pneumonia mouse model. Treatment with PC-SOD at 10 mg/kg significantly reduced the hydroxyproline content and fibrosis score. Namely, PC-SOD suppressed the progression of pulmonary fibrosis on the bleomycin-induced interstitial pneumonia mouse model. PC-SOD may be a potential drug for interstitial pneumonia therapy.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 75(1), 97-100, 1997-09-01

    The Japanese Pharmacological Society

References:  15

Cited by:  4

Codes

  • NII Article ID (NAID)
    10008679859
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    4307650
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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