Pathophysiological Effects of Dietary Essential Fatty Acid Balance on Neural Systems

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Author(s)

Abstract

Dietary fatty acid balance has been revealed to affect neural functions as well as chronic diseases such as cancer, cerebro- and cardiovascular diseases, and allergic hyper-reactivity. In this review, we focused on the pathophysiological effects of n-6 and n-3 fatty acids on brain functions. Long-term n-3 fatty acid deficiency in the presence of n-6 fatty acids has been shown to affect learning behavior, drug sensitivity and retinal functions. Some membrane enzymes and ion channel functions have been shown in experimental animals to be regulated by membrane fatty acid modifications. We also summarized the effects of these fatty acids in diets on human psychotic aspects and brain diseases. Although biochemical mechanisms remain to be elucidated, investigations on the effect of dietary fatty acids on neural networks may provide an important clue to clarify complex brain functions.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 77(1), 11-22, 1998-05-01

    The Japanese Pharmacological Society

References:  100

Cited by:  2

Codes

  • NII Article ID (NAID)
    10008679939
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    4503670
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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