Pathophysiological Effects of Dietary Essential Fatty Acid Balance on Neural Systems.
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- Yoshida Satoshi
- Research Laboratory Center, Oita Medical University
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- Sato Akira
- Faculty of Pharmaceutical Sciences, Nagoya City University
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- Okuyama Harumi
- Faculty of Pharmaceutical Sciences, Nagoya City University
Bibliographic Information
- Other Title
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- Pathophysiological Effects of Dietary E
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Abstract
Dietary fatty acid balance has been revealed to affect neural functions as well as chronic diseases such as cancer, cerebro- and cardiovascular diseases, and allergic hyper-reactivity. In this review, we focused on the pathophysiological effects of n-6 and n-3 fatty acids on brain functions. Long-term n-3 fatty acid deficiency in the presence of n-6 fatty acids has been shown to affect learning behavior, drug sensitivity and retinal functions. Some membrane enzymes and ion channel functions have been shown in experimental animals to be regulated by membrane fatty acid modifications. We also summarized the effects of these fatty acids in diets on human psychotic aspects and brain diseases. Although biochemical mechanisms remain to be elucidated, investigations on the effect of dietary fatty acids on neural networks may provide an important clue to clarify complex brain functions.
Journal
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- The Japanese Journal of Pharmacology
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The Japanese Journal of Pharmacology 77 (1), 11-22, 1998
The Japanese Pharmacological Society
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Details 詳細情報について
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- CRID
- 1390282679262019328
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- NII Article ID
- 10008679939
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- NII Book ID
- AA00691188
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- COI
- 1:CAS:528:DyaK1cXjsFSktLY%3D
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- ISSN
- 13473506
- 00215198
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- NDL BIB ID
- 4503670
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- PubMed
- 9639056
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- Web Site
- https://ndlsearch.ndl.go.jp/books/R000000004-I4503670
- https://api.elsevier.com/content/article/PII:S0021519819311424?httpAccept=text/xml
- https://api.elsevier.com/content/article/PII:S0021519819311424?httpAccept=text/plain
- https://www.jstage.jst.go.jp/article/jjp/77/1/77_1_11/_pdf
- https://search.jamas.or.jp/link/ui/1998204788
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed