Coronary Artery Diameter Increase Induced by a Phosphodiesterase 5 Inhibitor, E4021, in Conscious Pigs

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Author(s)

Abstract

The effects of intravenous infusions of 1, 3 and 10 μg/kg/min of the phosphodiesterase 5 inhibitor, E4021, at 30-min intervals on coronary artery diameter were studied in 8 conscious pigs monitored with a pair of piezoelectric crystals. The highest dose increased the diameter by 2.9±0.5% (P<0.01 vs vehicle) of the baseline diameter, with a significant decrease in mean pulmonary arterial pressure. However, there were no changes in mean aortic pressure and heart rate. Additionally, E4021 significantly prolonged the duration of the diameter increase induced by nitroglycerin. Thus, phosphodiesterase 5 inhibition causes coronary artery diameter increase and produces an amplifying effect with nitroglycerin.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 77(1), 99-102, 1998-05-01

    The Japanese Pharmacological Society

References:  15

Codes

  • NII Article ID (NAID)
    10008680307
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    00215198
  • NDL Article ID
    4503679
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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