Inhibition by [Arg8]-Vasopressin of Long Term Potentiation in Guinea Pig Hippocampal Slice

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抄録

We examined the effects of [Arg<SUP>8</SUP>]-vasopressin (AVP) on long term potentiation (LTP) of the field excitatory postsynaptic potentials at CA1 and CA3 synapses in adult guinea pig hippocampal slices. AVP (10 nM) depressed the magnitude of LTP without any effects on basal responses at both synaptic pathways. The depressive effect by AVP at CA1 synapses appears to be receptor-mediated since it was inhibited by an AVP V1-receptor antagonist, [Pmp<SUP>1</SUP>, Tyr(Me)<SUP>2</SUP>]-AVP. From these results, AVP may play an inhibitory role on the induction of LTP via V1 receptors in the guinea pig hippocampus.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 77(1), 103-105, 1998-05-01

    公益社団法人 日本薬理学会

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各種コード

  • NII論文ID(NAID)
    10008680323
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    4503680
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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