Functional Studies on Blockade by Neosurugatoxin of Nicotinic Receptors in Nitroxidergic and Sensory Nerve Terminals and Intramural Ganglionic Cells

Access this Article

Author(s)

Abstract

In isolated canine cerebral and cutaneous arteries and duodenum, effects of neosurugatoxin (NSTX) on the response to nicotine were compared. Nicotine-induced relaxations are mediated by nitric oxide (NO) from vasodilator nerves in cerebral arteries and by calcitonin gene-related peptide (CGRP) in cutaneous arteries treated with NO synthase inhibitors. Duodenal relaxation to nicotine is mediated by NO from inhibitory nerves. Cerebral arterial strips without endothelium responded to nicotine with relaxations that were inhibited by NSTX (3×10<SUP>-10</SUP> to 3×10<SUP>-9</SUP> M) concentration-dependently. Relaxations to nicotine of duodenal strips were attenuated by NSTX and abolished by tetrodotoxin, whereas those induced by K<SUP>+</SUP> and electrical stimulation were not influenced. In cutaneous arteries treated with <I>N</I><SUP>G</SUP>-nitro-L-arginine, nicotine-induced relaxations were attenuated by NSTX as low as 10<SUP>-10</SUP> M, but unaffected by tetrodotoxin. The inhibitory potency of NSTX was in the order of cutaneous artery > duodenum > cerebral artery. It is concluded that NSTX selectively antagonizes actions on nicotinic receptors in nitroxidergic nerves of cerebral arteries, CGRP-mediated sensory nerves of cutaneous artery and ganglionic cells of the duodenum, but the affinity of this toxin to nicotinic receptors in sensory nerves is the highest.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 78(2), 217-223, 1998-10-01

    The Japanese Pharmacological Society

References:  24

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008680860
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    4591519
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
Page Top