The Effect of Vasopressin V1- and V2-Receptor Antagonists on Hemodynamics in Early and Late Phase After Myocardial Infarction in Rats.

• Fujita Hisayoshi

  First Department of Internal Medicine, Osaka City University Medical School

• Yoshiyama Minoru

  First Department of Internal Medicine, Osaka City University Medical School

• Takeuchi Kazuhide

  First Department of Internal Medicine, Osaka City University Medical School

• Omura Takashi

  First Department of Internal Medicine, Osaka City University Medical School

• Yamagishi Hiroyuki

  First Department of Internal Medicine, Osaka City University Medical School

• Iwao Hiroshi

  Department of Pharmacology, Osaka City University Medical School

• Miura Katuyuki

  Department of Pharmacology, Osaka City University Medical School

• Yoshikawa Junichi

  First Department of Internal Medicine, Osaka City University Medical School

Bibliographic Information

Other Title

• Effect of Vasopressin V1-and V2-Recepto

Abstract

This study was designed to access the effect of a nonpeptide vasopressin V1-receptor antagonist, OPC-21268, and a vasopressin V2-receptor antagonist, OPC-31260, on hemodynamics in the early phase and the late phase after myocardial infarction in rats. In the early phase, OPC-21268 (30 mg/kg/day) or OPC-31260 (30 mg/kg/day) was orally administered from day 1 to days 5 after the operation; and hemodynamics were measured at day 5, in the late phase from 10 weeks to 11 weeks and measured at the end of 11 weeks. In the early phase, OPC-21268 reduced the left ventricular end-diastolic pressure (LVEDP) concomitantly with the reduction in systemic blood pressure, but did not change LVEDP in the late phase. OPC-31260 reduced LVEDP and central venous pressure in both phases. OPC-21268 improved hemodynamics only in the early phase and OPC-31260 improved it in both phases.

Journal

• The Japanese Journal of Pharmacology

  The Japanese Journal of Pharmacology 78 (2), 229-232, 1998

  The Japanese Pharmacological Society

Keywords

• Heart failure
• Myocardial infarction
• Vasopressin receptor antagonist

Details

• CRID: 1390001204287068800
• NII Article ID: 10008680901
• NII Book ID: AA00691188
• DOI: 10.1254/jjp.78.229
• COI: 1:CAS:528:DyaK1cXmvFyqsL0%3D
• ISSN: 13473506
• ISSN: 00215198
• NDL BIB ID: 4591521
• PubMed: 9829627
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4591521
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819310522?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819310522?httpAccept=text/plain
• Web Site: https://www.jstage.jst.go.jp/article/jjp/78/2/78_2_229/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1999076721
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed