Induction of Fas Ligand and Fas Antigen mRNA Expressions in Interferon-γ Transgenic Mouse Liver

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Author(s)

Abstract

The interferon-γ (IFN-γ) transgenic mouse develops chronic hepatitis. In the present study, lymphoid cell infiltration and expression of the Fas system were studied in the transgenic mouse liver. Morphological analysis showed the infiltration of lymphoid cells at the portal area and necro-inflammation piecemeal necrosis and the intralobular region. The polymerase chain reaction revealed induction of Fas antigen and Fas ligand mRNA expressions. The chronic hepatitis in this mouse reflects the profiles of human chronic hepatitis.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 78(2), 233-235, 1998-10-01

    The Japanese Pharmacological Society

References:  14

Cited by:  2

Codes

  • NII Article ID (NAID)
    10008680915
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    4591522
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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