In Vitro Effects of Calcium Dobesilate on the Responsiveness of Spontaneously Diabetic Rat Aorta
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We tested the effect of calcium dobesilate (DOBE) in aorta from spontaneously diabetic (BB/wor) rats. The contraction induced by 10<SUP>-6</SUP> M noradrenaline (NA) in BB/wor rats was smaller than that induced in control rats (1.21±0.11 vs 0.82±0.02 g, P<0.01, n=8, respectively) in arteries with intact endothelium. Incubation with DOBE (10<SUP>-4</SUP> M) impaired the contractions induced by NA in BB/wor rats (1.21±0.11 vs 0.67±0.01 g, P<0.01, n=8). The effect of DOBE was reversed by 10<SUP>-6</SUP> M propranolol (0.67±0.01 vs 1.20±0.60 g, P<0.001, n=8, with 10<SUP>-4</SUP> M DOBE and 10<SUP>-4</SUP> M DOBE plus 10<SUP>-6</SUP> M propranolol, respectively). DOBE increased the endothelium-dependent relaxation in arteries from diabetic rats. These findings suggest that DOBE might improve vascular reactivity in BB/wor rats.
- The Japanese Journal of Pharmacology
The Japanese Journal of Pharmacology 78(3), 391-394, 1998-11-01
The Japanese Pharmacological Society