Possible Mechanism of Hypoglycemic Effect of 4-Hydroxybenzoic Acid, a Constituent of Pandanus odorus Root
Access this Article
Search this Article
We studied the hypoglycemic effect of 4-hydroxybenzoic acid, a constituent of the root of <I>Pandanus odorus</I> Ridl. (Pandanaceae, Thai name: <I>Toei-hom</I>), in streptozotocin-diabetic rats. Oral administration of 4-hydroxybenzoic acid caused a decrease in plasma glucose levels dose-dependently in the diabetic rat. The constituent did not affect serum insulin level and liver glycogen content in the diabetic model, but increased glucose consumption in normal and diabetic rat diaphragms. These results suggest that 4-hydroxybenzoic acid produces a hypoglycemic effect mediated by an increase in the peripheral glucose consumption.
- The Japanese Journal of Pharmacology
The Japanese Journal of Pharmacology 78(3), 395-398, 1998-11-01
The Japanese Pharmacological Society