Possible Mechanism of Hypoglycemic Effect of 4-Hydroxybenzoic Acid, a Constituent of Pandanus odorus Root

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Author(s)

Abstract

We studied the hypoglycemic effect of 4-hydroxybenzoic acid, a constituent of the root of <I>Pandanus odorus</I> Ridl. (Pandanaceae, Thai name: <I>Toei-hom</I>), in streptozotocin-diabetic rats. Oral administration of 4-hydroxybenzoic acid caused a decrease in plasma glucose levels dose-dependently in the diabetic rat. The constituent did not affect serum insulin level and liver glycogen content in the diabetic model, but increased glucose consumption in normal and diabetic rat diaphragms. These results suggest that 4-hydroxybenzoic acid produces a hypoglycemic effect mediated by an increase in the peripheral glucose consumption.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 78(3), 395-398, 1998-11-01

    The Japanese Pharmacological Society

References:  11

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008681498
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    4610831
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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