Possible Mechanism of Hypoglycemic Effect of 4-Hydroxybenzoic Acid, a Constituent of Pandanus odorus Root.

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  • Peungvicha Penchom
    Department of Physiology, Faculty of Pharmacy, Mahidol University Department of Pharmacology, Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University
  • Thirawarapan Suwan S.
    Department of Physiology, Faculty of Pharmacy, Mahidol University
  • Watanabe Hiroshi
    Department of Pharmacology, Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University

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  • Possible Mechanism of Hypoglycemic Effe

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We studied the hypoglycemic effect of 4-hydroxybenzoic acid, a constituent of the root of Pandanus odorus Ridl. (Pandanaceae, Thai name: Toei-hom), in streptozotocin-diabetic rats. Oral administration of 4-hydroxybenzoic acid caused a decrease in plasma glucose levels dose-dependently in the diabetic rat. The constituent did not affect serum insulin level and liver glycogen content in the diabetic model, but increased glucose consumption in normal and diabetic rat diaphragms. These results suggest that 4-hydroxybenzoic acid produces a hypoglycemic effect mediated by an increase in the peripheral glucose consumption.

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  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 78 (3), 395-398, 1998

    公益社団法人 日本薬理学会

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