Heroin Antinociception Changed From Mu to Delta Receptor in Streptozotocin-Treated Mice
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- Rady Jodie J.
- Research Service, Clement J. Zablocki Veterans Affairs Medical Center
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- Gorny Jennifer M.
- Research Service, Clement J. Zablocki Veterans Affairs Medical Center
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- Fujimoto James M.
- Research Service, Clement J. Zablocki Veterans Affairs Medical Center
Bibliographic Information
- Other Title
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- Heroin Antinociception Changed From Mu
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Abstract
CD-1 mice were treated intravenously with streptozotocin, 200 mg/kg, and tested 2 weeks later or treated with 60 mg/kg and tested 3 days later. Both treatments changed the tail flick response of heroin and 6-monoacetylmorphine (6 MAM) given intracerebroventricularly from a μ- to δ-opioid receptor-mediated action as determined by differential effects of opioid receptor antagonists. The response to morphine remained μ. Heroin and 6 MAM responses involved δ1 (inhibited by 7-benzylidenenaltrexone) and δ2 (inhibited by naltriben) receptors, respectively. These δ-agonist actions did not synergize with the μ-agonist action of morphine in the diabetic mice. The expected synergism between the δ agonist, [D-Pen2-D-Pen5]enkephalin (DPDPE), and morphine was not obtained in diabetic mice. Thus, diabetes disrupted the purported μ/δ-coupled response. In nondiabetic CD-1 mice, heroin and 6 MAM produced a different μ-receptor response (not inhibited by naloxonazine) from that of morphine (inhibited by naloxonazine). Also, these μ actions, unlike that of morphine, did not synergize with DPDPE. The unique receptor actions and changes produced by streptozotocin suggest that extrinsic in addition to genetic factors influence the opioid receptor selectivity of heroin and 6 MAM.
Journal
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- The Japanese Journal of Pharmacology
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The Japanese Journal of Pharmacology 78 (4), 443-454, 1998
The Japanese Pharmacological Society
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Details 詳細情報について
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- CRID
- 1390001204287122560
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- NII Article ID
- 10008681706
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- NII Book ID
- AA00691188
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- COI
- 1:CAS:528:DyaK1MXhvFWmtQ%3D%3D
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- ISSN
- 13473506
- 00215198
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- NDL BIB ID
- 4629549
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- PubMed
- 9920201
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- Web Site
- https://ndlsearch.ndl.go.jp/books/R000000004-I4629549
- https://api.elsevier.com/content/article/PII:S002151981931008X?httpAccept=text/xml
- https://api.elsevier.com/content/article/PII:S002151981931008X?httpAccept=text/plain
- https://www.jstage.jst.go.jp/article/jjp/78/4/78_4_443/_pdf
- https://search.jamas.or.jp/link/ui/1999110658
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed