Local Anti-inflammatory Activity and Systemic Side Effects of NM-135, a New Prodrug Glucocorticoid, in an Experimental Inflammatory Rat Model

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Author(s)

Abstract

The local anti-inflammatory activity and systemic side effects of NM-135 (6α, 9-difluoro-11β-hydroxy-16α-methyl-21[[2, 3, 4, 6-tetrakis-<I>O</I>-(4-methylbenzoyl)-β-D-glucopyranosyl]oxy]-pregna-1, 4-diene-3, 20-dione) in croton oil-induced granuloma pouches and ear edema in rats were studied. The local anti-inflammatory activity of NM-135 was stronger than that of betamethasone 17-valerate (BV). As to systemic side effects, BV and diflucortolon valerate (DFV) caused thymolysis at the doses required for the anti-inflammatory activity. In contrast, no clear systemic side effect was observed in rats administered NM-135 at the dose producing the anti-inflammatory activity. These results suggest that NM-135 is a drug exhibiting a high degree of dissociation between the local anti-inflammatory activity and systemic side effects.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 78(4), 505-509, 1998-12-01

    The Japanese Pharmacological Society

References:  15

Codes

  • NII Article ID (NAID)
    10008681970
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    00215198
  • NDL Article ID
    4629557
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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