Serotonin Receptor Subtypes Involved in Modulation of Electrical Acupuncture

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Author(s)

Abstract

We examined the effects of intravenous injection of several serotonin (5-HT) antagonists on the inhibitory action of electro-acupuncture (EAP) against the nociceptive responses in the trigeminal nucleus caudalis in rabbits. The inhibitory effect of EAP was suppressed by pindolol, methysergide and ICS 205-930, whereas NAN-190 and ketanserin amplified the EAP effect. These results suggest that 5-HT<SUB>1</SUB>, except 5-HT<SUB>1A</SUB>; 5-HT<SUB>2</SUB>, except 5-HT<SUB>2A</SUB>; and 5-HT<SUB>3</SUB> receptors are positively involved in EAP-induced analgesia, whereas the activation of 5-HT<SUB>1A</SUB> and 5-HT<SUB>2A</SUB> receptors suppressively act on EAP-induced analgesia.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 78(4), 511-514, 1998-12-01

    The Japanese Pharmacological Society

References:  15

Cited by:  3

Codes

  • NII Article ID (NAID)
    10008681986
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    4629558
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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