Teprenone, an Anti-ulcer Agent, Increases Gastric Mucosal Mucus Level via Nitric Oxide in Rats

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Author(s)

Abstract

We examined whether the increasing action of teprenone (TP) on mucus synthesis and content in rat gastric mucosa is related to nitric oxide (NO) formation via NO synthase (NOS) in the tissue. TP (200 mg/kg)-induced increases in levels of gastric mucosal hexosamine and adherent mucus were inhibited with decreased gastric mucosal NOS activity and nitrite/nitrate concentration by co-administration of <I>N</I><SUP>G</SUP>-monomethyl L-arginine (100 mg/kg), a NOS inhibitor, but not its D-isomer. These results suggest that TP exerts an increasing action on gastric mucus synthesis and content possibly under the condition of maintained NO production via NOS in gastric mucosal tissues, although the precise mechanisms for the action of TP is still unclear.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 78(4), 519-522, 1998-12-01

    The Japanese Pharmacological Society

References:  15

Cited by:  4

Codes

  • NII Article ID (NAID)
    10008682013
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    4629560
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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