Antinociceptive Effect of Gosha-jinki-gan, a Kampo Medicine, in Streptozotocin-Induced Diabetic Mice

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Author(s)

Abstract

We evaluated the antinociceptive effect of <I>Gosha-jinki-gan</I>, a <I>Kampo</I> medicine including processed <I>Aconiti</I> tuber, and its mechanism in streptozotocin-induced diabetic mice. <I>Gosha-jinki-gan</I> (0.1 - 1.0 g/kg, p.o.) showed a more potent antinociceptive effect in diabetic mice than in non-diabetic mice. The antinociceptive effect of <I>Gosha-jinki-gan</I> (0.3 g/kg, p.o.) in diabetic mice was inhibited by administration of either anti-dynorphin antiserum (5 μg, i.t.) or nor-binaltorphimine (10 mg/kg, s.c.), a κ-opioid antagonist. The antinociceptive activity of <I>Gosha-jinki-gan</I> (0.3, 1.0 g/kg, p.o.) was decreased by excluding processed <I>Aconiti</I> tuber. Furthermore, the antinociceptive effect of processed <I>Aconiti</I> tuber (0.03, 0.1 g/kg, p.o.) was also shown to be enhanced in diabetic mice. These results suggest that the increased antinociceptive effect of <I>Gosha-jinki-gan</I> in diabetic mice is partly derived from the action of processed <I>Aconiti</I> tuber and that it is based on stimulation of spinal κ-opioid receptors via dynorphin release. <I>Gosha-jinki-gan</I> was considered useful for treating painful diabetic neuropathy.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 79(2), 169-175, 1999-02-01

    The Japanese Pharmacological Society

References:  27

Cited by:  4

Codes

  • NII Article ID (NAID)
    10008682236
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    4663447
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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