Antinociceptive Effect of Gosha-jinki-gan, a Kampo Medicine, in Streptozotocin-Induced Diabetic Mice.
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- Suzuki Yasuyuki
- Kampo and Pharmacognosy Laboratories, Tsumura & Co.
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- Goto Kazuhiro
- Kampo and Pharmacognosy Laboratories, Tsumura & Co.
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- Ishige Atsushi
- Kampo and Pharmacognosy Laboratories, Tsumura & Co.
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- Komatsu Yasuhiro
- Kampo and Pharmacognosy Laboratories, Tsumura & Co.
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- Kamei Junzo
- Department of Pathophysiology & Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University,
Bibliographic Information
- Other Title
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- Antinociceptive Effect of Gosha-jinki-gan, a Kampo Medicine, in Streptozotochin-Induced Diabetic Mice
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Abstract
We evaluated the antinociceptive effect of Gosha-jinki-gan, a Kampo medicine including processed Aconiti tuber, and its mechanism in streptozotocin-induced diabetic mice. Gosha-jinki-gan (0.1 - 1.0 g/kg, p.o.) showed a more potent antinociceptive effect in diabetic mice than in non-diabetic mice. The antinociceptive effect of Gosha-jinki-gan (0.3 g/kg, p.o.) in diabetic mice was inhibited by administration of either anti-dynorphin antiserum (5 μg, i.t.) or nor-binaltorphimine (10 mg/kg, s.c.), a κ-opioid antagonist. The antinociceptive activity of Gosha-jinki-gan (0.3, 1.0 g/kg, p.o.) was decreased by excluding processed Aconiti tuber. Furthermore, the antinociceptive effect of processed Aconiti tuber (0.03, 0.1 g/kg, p.o.) was also shown to be enhanced in diabetic mice. These results suggest that the increased antinociceptive effect of Gosha-jinki-gan in diabetic mice is partly derived from the action of processed Aconiti tuber and that it is based on stimulation of spinal κ-opioid receptors via dynorphin release. Gosha-jinki-gan was considered useful for treating painful diabetic neuropathy.
Journal
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- The Japanese Journal of Pharmacology
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The Japanese Journal of Pharmacology 79 (2), 169-175, 1999
The Japanese Pharmacological Society
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Details 詳細情報について
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- CRID
- 1390282679261309568
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- NII Article ID
- 10008682236
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- NII Book ID
- AA00691188
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- COI
- 1:CAS:528:DyaK1MXhsFyktr8%3D
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- ISSN
- 13473506
- 00215198
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- NDL BIB ID
- 4663447
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- PubMed
- 10202852
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- Web Site
- https://ndlsearch.ndl.go.jp/books/R000000004-I4663447
- https://api.elsevier.com/content/article/PII:S0021519819309679?httpAccept=text/xml
- https://api.elsevier.com/content/article/PII:S0021519819309679?httpAccept=text/plain
- https://www.jstage.jst.go.jp/article/jjp/79/2/79_2_169/_pdf
- https://search.jamas.or.jp/link/ui/1999165448
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed