Benzodiazepine Receptor Agonists Modulate Thymocyte Apoptosis Through Reduction of the Mitochondrial Transmembrane Potential

DOI Web Site Web Site Web Site Web Site ほか1件をすべて表示 一部だけ表示 被引用文献2件 参考文献47件

書誌事項

タイトル別名
  • Benzodiazepine Receptor Agonists Modulate Thymocyte Apoptosis Though Reduction of the Mitochondrial Transmembrane Potential

この論文をさがす

抄録

Peripheral-type benzodiazepines have been shown to exert immunological effects. In this study, we examined the effects of the peripheral-type benzodiazepines on murine thymocytes. Murine thymocytes that were incubated with the peripheral-type benzodiazepines underwent apoptosis associated with the collapse of mitochondrial transmembrane potential (Δφm). The drugs stimulated dexamethasone- and etoposide-induced apoptosis with the enhanced collapse of Δφm. The central-type benzodiazepines had no effect on either the Δφm or apoptosis. The reduction of Δφm depended on protein synthesis and protein phosphorylation. These results suggest that the immunomodulating effect of benzodiazepines is in part due to the modulation of thymocyte apoptosis associated with the collapse of Δφm.

収録刊行物

  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 79 (2), 177-183, 1999

    公益社団法人 日本薬理学会

被引用文献 (2)*注記

もっと見る

参考文献 (47)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ