Benzodiazepine Receptor Agonists Modulate Thymocyte Apoptosis Through Reduction of the Mitochondrial Transmembrane Potential

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Author(s)

Abstract

Peripheral-type benzodiazepines have been shown to exert immunological effects. In this study, we examined the effects of the peripheral-type benzodiazepines on murine thymocytes. Murine thymocytes that were incubated with the peripheral-type benzodiazepines underwent apoptosis associated with the collapse of mitochondrial transmembrane potential (Δφ<SUB>m</SUB>). The drugs stimulated dexamethasone- and etoposide-induced apoptosis with the enhanced collapse of Δφ<SUB>m</SUB>. The central-type benzodiazepines had no effect on either the Δφ<SUB>m</SUB> or apoptosis. The reduction of Δφ<SUB>m</SUB> depended on protein synthesis and protein phosphorylation. These results suggest that the immunomodulating effect of benzodiazepines is in part due to the modulation of thymocyte apoptosis associated with the collapse of Δφ<SUB>m</SUB>.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 79(2), 177-183, 1999-02-01

    The Japanese Pharmacological Society

References:  29

Codes

  • NII Article ID (NAID)
    10008682264
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    REV
  • ISSN
    00215198
  • NDL Article ID
    4663466
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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