Effects of Exogenous [Arg^8]-Vasopressin on Borderline-Hypertensive Hiroshima Rats
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The interaction between [Arg<SUP>8</SUP>]-vasopressin and a vasopressin receptor antagonist, [d(CH<SUB>2</SUB>)<SUB>5</SUB><SUP>1</SUP>, O-Me-Tyr<SUP>2</SUP>, Arg<SUP>8</SUP>]-vasopressin, was examined in Hiroshima rats and normotensive control rats under pentobarbital anesthesia. [Arg<SUP>8</SUP>]-vasopressin dose-dependently increased the arterial pressure in both the Hiroshima and control rats, the pressor effect being greater in the Hiroshima rats. After the administration of a vasopressin antagonist (0.01 mg/kg), which by itself decreased arterial pressure only in the Hiroshima rats, the dose-response curve for [Arg<SUP>8</SUP>]-vasopressin was much more greatly shifted to the right in the control rats. These results indicate that with or without a vasopressin antagonist, the exogenous [Arg<SUP>8</SUP>]-vasopressin induced more powerful pressor actions in the Hiroshima rats compared to the control rats.
- The Japanese Journal of Pharmacology
The Japanese Journal of Pharmacology 79(2), 251-255, 1999-02-01
The Japanese Pharmacological Society