Effects of Exogenous [Arg^8]-Vasopressin on Borderline-Hypertensive Hiroshima Rats

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Author(s)

Abstract

The interaction between [Arg<SUP>8</SUP>]-vasopressin and a vasopressin receptor antagonist, [d(CH<SUB>2</SUB>)<SUB>5</SUB><SUP>1</SUP>, O-Me-Tyr<SUP>2</SUP>, Arg<SUP>8</SUP>]-vasopressin, was examined in Hiroshima rats and normotensive control rats under pentobarbital anesthesia. [Arg<SUP>8</SUP>]-vasopressin dose-dependently increased the arterial pressure in both the Hiroshima and control rats, the pressor effect being greater in the Hiroshima rats. After the administration of a vasopressin antagonist (0.01 mg/kg), which by itself decreased arterial pressure only in the Hiroshima rats, the dose-response curve for [Arg<SUP>8</SUP>]-vasopressin was much more greatly shifted to the right in the control rats. These results indicate that with or without a vasopressin antagonist, the exogenous [Arg<SUP>8</SUP>]-vasopressin induced more powerful pressor actions in the Hiroshima rats compared to the control rats.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 79(2), 251-255, 1999-02-01

    The Japanese Pharmacological Society

References:  8

Cited by:  2

Codes

  • NII Article ID (NAID)
    10008682560
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    4663655
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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