Chronic Hepatitis in Interferon-γ Transgenic Mice Is Associated With Elevated CPP32-Like Activity and Interleukin-1β-Converting Enzyme Activity Suppression

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抄録

Interferon-γ (IFN-γ) transgenic mice strongly express IFN-γ in the liver and develop chronic hepatitis. Furthermore, hepatocyte apoptosis was shown by the TdT-mediated dUTP-biotin nick endlabel- ing method. In the present study, interleukin-1β-converting enzyme (ICE) and CPP32-like protease activ- ities in the liver of IFN-γ transgenic mice were measured, using the synthetic substrates Ac-YVAD-MCA and Ac-DEVD-MCA. Plasma aspartate aminotransferase and alanine aminotransferase activities as well as CPP32-like activity were significantly elevated, while ICE activity was significantly reduced. The addition of the ICE inhibitor Ac-YVAD-CHO to IFN-γ transgenic mouse liver cell cytosol had no effect on the CPP32 activity, in contrast to a CPP32 inhibitor. The present results indicate that chronic hepatitis in the IFN-γ transgenic mouse is associated with a decrease in ICE and induction of CPP32-like activity.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 79(3), 289-294, 1999-03-01

    The Japanese Pharmacological Society

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各種コード

  • NII論文ID(NAID)
    10008682689
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    REV
  • ISSN
    00215198
  • NDL 記事登録ID
    4699119
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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