Chronic Hepatitis in Interferon-γ Transgenic Mice is Associated with Elevated CPP32-Like Activity and Interleukin-1β-Converting Enzyme Activity Suppression
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- Okamoto Toshihiro
- Research Laboratories, Nippon Chemiphar Co., Ltd.
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- Nakano Yoshihisa
- Research Laboratories, Nippon Chemiphar Co., Ltd.
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- Yamakawa Tomio
- Research Laboratories, Nippon Chemiphar Co., Ltd.
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- Hara Kaoru
- Research Laboratories, Nippon Chemiphar Co., Ltd.
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- Yamamura Ken-Ichi
- Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine
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- Hino Okio
- Department of Experimental Pathology, Cancer Institute
書誌事項
- タイトル別名
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- Chronic Hepatitis in Interferon-.GAMMA. Transgenic Mice Is Associated With Elevated CPP32-Like Activity and Interleukin-1.BETA.-Converting Enzyme Activity Suppression.
- Chronic Hepatitis in Interferon-ガンマ Transgenic Mice Is Associated With Elevated CPP32-Like Activity and Interleukin-1 ベーターConverting Enzyme Activity Suppression
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抄録
Interferon-γ (IFN-γ) transgenic mice strongly express IFN-γ in the liver and develop chronic hepatitis. Furthermore, hepatocyte apoptosis was shown by the TdT-mediated dUTP-biotin nick endlabel- ing method. In the present study, interleukin-1β-converting enzyme (ICE) and CPP32-like protease activ- ities in the liver of IFN-γ transgenic mice were measured, using the synthetic substrates Ac-YVAD-MCA and Ac-DEVD-MCA. Plasma aspartate aminotransferase and alanine aminotransferase activities as well as CPP32-like activity were significantly elevated, while ICE activity was significantly reduced. The addition of the ICE inhibitor Ac-YVAD-CHO to IFN-γ transgenic mouse liver cell cytosol had no effect on the CPP32 activity, in contrast to a CPP32 inhibitor. The present results indicate that chronic hepatitis in the IFN-γ transgenic mouse is associated with a decrease in ICE and induction of CPP32-like activity.
収録刊行物
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- Jpn.J.Pharmacol.
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Jpn.J.Pharmacol. 79 (3), 289-294, 1999
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390282679261688832
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- NII論文ID
- 10008682689
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- NII書誌ID
- AA00691188
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- COI
- 1:CAS:528:DyaK1MXitFCltrY%3D
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- ISSN
- 13473506
- 00215198
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- NDL書誌ID
- 4699119
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- PubMed
- 10230856
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- Web Site
- https://ndlsearch.ndl.go.jp/books/R000000004-I4699119
- https://api.elsevier.com/content/article/PII:S0021519819309461?httpAccept=text/xml
- https://api.elsevier.com/content/article/PII:S0021519819309461?httpAccept=text/plain
- https://www.jstage.jst.go.jp/article/jjp/79/3/79_3_289/_pdf
- https://search.jamas.or.jp/link/ui/1999161362
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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