Analgesia-Producing Mechanism of Processed Aconiti Tuber-Role of Dynorphin an Endogenous k-Opioid Ligand,in the Rodent Spinal Cord

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Abstract

The analgesia-producing mechanism of processed <I>Aconiti</I> tuber was examined using rodents whose nociceptive threshold was decreased by loading repeated cold stress (RCS). The antinociceptive effect of processed <I>Aconiti</I> tuber (0.3 g/kg, p.o.) in RCS-loaded mice was antagonized by pretreatment with a κ-opioid antagonist, nor-binaltorphimine (10 mg/kg, s.c.), and was abolished by an intrathecal injection of anti-dynorphin antiserum (5 μg). The <I>Aconiti</I> tuber-induced antinociception was inhibited by both dexamethasone (0.4 mg/kg, i.p.) and a dopamine D<SUB>2</SUB> antagonist, sulpiride (10 mg/kg, i.p.), in RCS-loaded mice, and it was eliminated by both an electric lesion of the hypothalamic arcuate nucleus (HARN) and a highly selective dopamine D<SUB>2</SUB> antagonist, eticlopride (0.05 μg), administered into the HARN in RCS-loaded rats. These results suggest that the analgesic effect of processed <I>Aconiti</I> tuber was produced via the stimulation of κ-opioid receptors by dynorphin released in the spinal cord. It was also shown that dopamine D<SUB>2</SUB> receptors in the HARN were involved in the expression of the analgesic activity of processed <I>Aconiti</I> tuber.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 79(3), 295-301, 1999-03-01

    The Japanese Pharmacological Society

References:  19

Cited by:  9

Codes

  • NII Article ID (NAID)
    10008682712
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    4699210
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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