Analgesia-Producing Mechanism of Processed Aconiti Tuber:Role of Dynorphin,an Endogenous κ-Opioid Ligand, in the Rodent Spinal Cord
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- Omiya Yuji
- Kampo and Pharmacognosy Laboratories, Tsumura & Co.
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- Goto Kazuhiro
- Kampo and Pharmacognosy Laboratories, Tsumura & Co.
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- Suzuki Yasuyuki
- Kampo and Pharmacognosy Laboratories, Tsumura & Co.
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- Ishige Atsushi
- Kampo and Pharmacognosy Laboratories, Tsumura & Co.
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- Komatsu Yasuhiro
- Kampo and Pharmacognosy Laboratories, Tsumura & Co.
書誌事項
- タイトル別名
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- Analgesia-Producing Mechanism of Processed Aconiti Tuber: Role of Dynorphin, an Endogenous .KAPPA.-Opioid Ligand, in the Rodent Spinal Cord.
- Analgesia-Producing Mechanism of Processed Aconiti Tuber Role of Dynorphin an Endogenous カッパーOpioid Ligand in the Rodent Spinal Cord
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The analgesia-producing mechanism of processed Aconiti tuber was examined using rodents whose nociceptive threshold was decreased by loading repeated cold stress (RCS). The antinociceptive effect of processed Aconiti tuber (0.3 g/kg, p.o.) in RCS-loaded mice was antagonized by pretreatment with a κ-opioid antagonist, nor-binaltorphimine (10 mg/kg, s.c.), and was abolished by an intrathecal injection of anti-dynorphin antiserum (5 μg). The Aconiti tuber-induced antinociception was inhibited by both dexamethasone (0.4 mg/kg, i.p.) and a dopamine D2 antagonist, sulpiride (10 mg/kg, i.p.), in RCS-loaded mice, and it was eliminated by both an electric lesion of the hypothalamic arcuate nucleus (HARN) and a highly selective dopamine D2 antagonist, eticlopride (0.05 μg), administered into the HARN in RCS-loaded rats. These results suggest that the analgesic effect of processed Aconiti tuber was produced via the stimulation of κ-opioid receptors by dynorphin released in the spinal cord. It was also shown that dopamine D2 receptors in the HARN were involved in the expression of the analgesic activity of processed Aconiti tuber.
収録刊行物
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- Jpn.J.Pharmacol.
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Jpn.J.Pharmacol. 79 (3), 295-301, 1999
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390001204284979328
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- NII論文ID
- 10008682712
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- NII書誌ID
- AA00691188
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- COI
- 1:CAS:528:DyaK1MXitFCltrc%3D
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- ISSN
- 13473506
- 00215198
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- NDL書誌ID
- 4699210
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- PubMed
- 10230857
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- Web Site
- https://ndlsearch.ndl.go.jp/books/R000000004-I4699210
- https://api.elsevier.com/content/article/PII:S0021519819309473?httpAccept=text/xml
- https://api.elsevier.com/content/article/PII:S0021519819309473?httpAccept=text/plain
- https://www.jstage.jst.go.jp/article/jjp/79/3/79_3_295/_pdf
- https://search.jamas.or.jp/link/ui/1999156956
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可