Antinociceptive Mechanism of Gosha-jinki-gan in StreptozotocinInduced Diabetic Animals: Role of Nitric Oxide in the Periphery

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Abstract

Using streptozotocin-induced diabetic mice and rats, we evaluated the antinociceptive mechanism of <I>Gosha-jinki-gan</I>. The antinociceptive effect of <I>Gosha-jinki-gan</I> (0.3 g/kg, p.o.) in diabetic mice, as determined by the tail-pressure test, was inhibited by <I>N</I><SUP>G</SUP>-nitro-L-arginine methyl ester (L-NAME; 2, 5 mg/kg, i.p.). When L-NAME (10 μg) or methylene blue (500 μg) was topically administered to the intraplantar area of the hind paw, the region used for the paw-pressure test, the antinociceptive activity of <I>Gosha-jinki-gan</I> (0.3 g/kg, p.o.) in diabetic rats was decreased. These results suggested that the antinociceptive effect of <I>Gosha-jinki-gan</I> partly resulted from the peripheral action of increasingly produced nitric oxide.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 79(3), 387-391, 1999-03-01

    The Japanese Pharmacological Society

References:  15

Cited by:  6

Codes

  • NII Article ID (NAID)
    10008683037
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    4699784
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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