Effects of Nicotinic Receptor Agonists on Beta-Amyloid Beta-Sheet Formation

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Author(s)

Abstract

Previously we demonstrated that nicotinic acetylcholine receptor stimulation protects neurons against beta-amyloid (Aβ)-induced cytotoxicity. In the present study, the effects of nicotinic receptor agonists on the β-sheet formation were investigated using a thioflavin T (ThT)-based fluorescence assay. Nicotine, cytisine (an α4β2 agonist), and 3-(2, 4)-dimethoxybenzylidene anabaseine (DMXB, an α7 agonist) did not reduce fluorescence intensity when these agents were added to the β-sheet-formed Aβ. Simultaneous incubation of Aβ with nicotinic agonists also did not cause a reduction in fluorescence intensity. This data suggests that nicotinic receptor agonists do not influence the formation of the β-sheet structure.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 79(3), 393-396, 1999-03-01

    The Japanese Pharmacological Society

References:  15

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008683053
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    4699301
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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