The Effect of Tulobuterol Tape on Histamine-Induced Bronchoconstriction in Conscious Guinea Pigs:Long Duration of Action
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The objective of the present study was to determine the action duration of tulobuterol tape within a 24-hr period in conscious guinea pigs. The bronchoconstriction induced by histamine-inhalation was significantly inhibited by tulobuterol tape in comparison with its placebo tape 8 and 12 hr after binding, and the inhibitory rate was 50±11% and 35±13%, respectively. Twenty-four hours after binding, the inhibitory effect of tulobuterol tape gradually diminished, but the inhibitory rate was maintained at 30±14%. These results suggests that tulobuterol tape has a long lasting bronchodilatory action.
- The Japanese Journal of Pharmacology
The Japanese Journal of Pharmacology 79(3), 401-402, 1999-03-01
The Japanese Pharmacological Society