The Effect of Tulobuterol Tape on Histamine-Induced Bronchoconstriction in Conscious Guinea Pigs: Long Duration of Action.

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  • Musoh Keiichi
    Research and Development Division, Hokuriku Seiyaku Co., Ltd.
  • Kawamura Kayoko
    Research and Development Division, Hokuriku Seiyaku Co., Ltd.
  • Miyake Isao
    Research and Development Division, Hokuriku Seiyaku Co., Ltd.
  • Shimada Shino
    Research and Development Division, Hokuriku Seiyaku Co., Ltd.
  • Ohashi Tetsuo
    Research and Development Division, Hokuriku Seiyaku Co., Ltd.
  • Iwanaga Yuji
    Research and Development Division, Hokuriku Seiyaku Co., Ltd.
  • Morikawa Kouji
    Research and Development Division, Hokuriku Seiyaku Co., Ltd.
  • Kato Hideo
    Research and Development Division, Hokuriku Seiyaku Co., Ltd.

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Abstract

The objective of the present study was to determine the action duration of tulobuterol tape within a 24-hr period in conscious guinea pigs. The bronchoconstriction induced by histamine-inhalation was significantly inhibited by tulobuterol tape in comparison with its placebo tape 8 and 12 hr after binding, and the inhibitory rate was 50±11% and 35±13%, respectively. Twenty-four hours after binding, the inhibitory effect of tulobuterol tape gradually diminished, but the inhibitory rate was maintained at 30±14%. These results suggests that tulobuterol tape has a long lasting bronchodilatory action.

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