The Effect of Tulobuterol Tape on Histamine-Induced Bronchoconstriction in Conscious Guinea Pigs:Long Duration of Action

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Author(s)

    • MUSOH Keiichi
    • Research and Development Division, Hokuriku Seiyaku Co., Ltd
    • MIYAKE Isao
    • Research and Development Division, Hokuriku Seiyaku Co., Ltd
    • SHIMADA Shino
    • Research and Development Division, Hokuriku Seiyaku Co., Ltd
    • OHASHI Tetsuo
    • Research and Development Division, Hokuriku Seiyaku Co., Ltd
    • IWANAGA Yuji
    • Research and Development Division, Hokuriku Seiyaku Co., Ltd
    • KATO Hideo
    • Research and Development Division, Hokuriku Seiyaku Co., Ltd

Abstract

The objective of the present study was to determine the action duration of tulobuterol tape within a 24-hr period in conscious guinea pigs. The bronchoconstriction induced by histamine-inhalation was significantly inhibited by tulobuterol tape in comparison with its placebo tape 8 and 12 hr after binding, and the inhibitory rate was 50±11% and 35±13%, respectively. Twenty-four hours after binding, the inhibitory effect of tulobuterol tape gradually diminished, but the inhibitory rate was maintained at 30±14%. These results suggests that tulobuterol tape has a long lasting bronchodilatory action.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 79(3), 401-402, 1999-03-01

    The Japanese Pharmacological Society

References:  4

Codes

  • NII Article ID (NAID)
    10008683085
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    00215198
  • Data Source
    CJP  J-STAGE 
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