Effects of Imipramine, an Uptake Inhibitor, on Double-Peaked Constrictor Responses to Periarterial Nerve Stimulation in Isolated, Perfused Canine Splenic Arteries.
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- Yang Xiao-Ping
- Department of Pharmacology, Shinshu University School of Medicine
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- Chiba Shigetoshi
- Department of Pharmacology, Shinshu University School of Medicine
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Abstract
Using a cannula insertion method, periarterial nerve electrical stimulations were performed at 1 and 10 Hz in the isolated, perfused canine splenic artery. Electrical nerve stimulation readily caused double-peaked vasoconstrictions. The 1st-peak response at 1 Hz was not influenced by treatment with imipramine but the 2nd one was significantly enhanced by it. The 2nd-peak response was markedly blocked by prazosin. An additional treatment with α, β-methylene ATP, a P2X-purinoceptor desensitizer, abolished electrical stimulation-induced vascular responses that remained. At 10 Hz, the responses to electrical stimulation were not significantly influenced by imipramine. On the other hand, the imipramine treatment inhibited the tyramine-induced vasoconstriction but potentiated the noradrenaline-induced one. ATP-induced responses were not modified by imipramine. From these results, it is concluded that 1) the 1st-peaked constriction is mainly due to a P2X-purinoceptor-dependent mechanism, 2) the 2nd one is mainly due to an α1-adrenoceptor-dependent mechanism, and 3) presynaptic uptake mechanisms may perform an important role in the regulation of vascular reactivity, especially at a low frequency.
Journal
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- The Japanese Journal of Pharmacology
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The Japanese Journal of Pharmacology 79 (4), 461-466, 1999
The Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390282679264125312
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- NII Article ID
- 10008683533
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- NII Book ID
- AA00691188
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- COI
- 1:CAS:528:DyaK1MXislejtbc%3D
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- ISSN
- 13473506
- 00215198
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- NDL BIB ID
- 4706115
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- PubMed
- 10361886
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- Web Site
- https://ndlsearch.ndl.go.jp/books/R000000004-I4706115
- https://api.elsevier.com/content/article/PII:S002151981930928X?httpAccept=text/xml
- https://api.elsevier.com/content/article/PII:S002151981930928X?httpAccept=text/plain
- https://www.jstage.jst.go.jp/article/jjp/79/4/79_4_461/_pdf
- https://search.jamas.or.jp/link/ui/1999203375
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed