The Protective Effect of Cyclosporine A on Anti-Fas Antibody-Induced Hepatitis in Mice.
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- Okamoto Toshihiro
- Research Laboratories, Nippon Chemiphar Co., Ltd.
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- Hitomi Yuji
- Zeria Pharmaceutical Co., Ltd.
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- Hara Atsuko
- Research Laboratories, Nippon Chemiphar Co., Ltd.
Bibliographic Information
- Other Title
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- Protective Effect of Cyclosporine A on Anti-Fas Antibody-Induced Hepatitis in Mice
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Abstract
The effect of cyclosporine A (CsA) on anti-Fas antibody-induced hepatitis was studied. The administration of anti-Fas antibody (250 μg/kg) to mice elevated plasma alanine aminotransferase (ALT) activity at 3 hr. This anti-Fas antibody-induced elevation of ALT was inhibited by treatment with CsA (10, 30 and 100 mg/kg) in a dose-dependent manner. Anti-Fas antibody administration elevated CPP32-like protease activity at 3 hr in mouse liver, and this elevation of CPP32-like activity was inhibited by treatment with CsA. The present results show that CsA treatment inhibits the anti-Fas antibody-induced apoptotic process of hepatitis, at least in part, by affecting a reaction upstream of CPP32-like protease activation.
Journal
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- The Japanese Journal of Pharmacology
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The Japanese Journal of Pharmacology 79 (4), 485-488, 1999
The Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390001204287415680
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- NII Article ID
- 10008683635
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- NII Book ID
- AA00691188
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- COI
- 1:CAS:528:DyaK1MXislejurw%3D
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- ISSN
- 13473506
- 00215198
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- NDL BIB ID
- 4706179
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- PubMed
- 10361889
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- Web Site
- https://ndlsearch.ndl.go.jp/books/R000000004-I4706179
- https://api.elsevier.com/content/article/PII:S002151981930931X?httpAccept=text/xml
- https://api.elsevier.com/content/article/PII:S002151981930931X?httpAccept=text/plain
- https://www.jstage.jst.go.jp/article/jjp/79/4/79_4_485/_pdf
- https://search.jamas.or.jp/link/ui/1999207121
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed