Ability of Mosapride to Bind to 5-HT_4 Receptor in the Human Stomach

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Author(s)

Abstract

Ability of mosapride, a gastrokinetic agent, to bind to 5-HT<SUB>4</SUB> receptor was examined in the stomach of human and guinea pig by in vitro receptor autoradiography. [<SUP>125</SUP>I]SB207710 binding sites were detected in the muscle layer including the myenteric plexus of the stomach from both humans and guinea pigs, although the binding was observed more clearly and densely in the stomach of guinea pigs than humans. Mosapride as well as SB204070 inhibited the binding of [<SUP>125</SUP>I]SB207710. Thus, mosapride possesses the ability to bind to 5-HT<SUB>4</SUB> receptors of human stomach and may modulate the motility, as in the case of guinea pig stomach.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 79(4), 493-496, 1999-04-01

    The Japanese Pharmacological Society

References:  14

Cited by:  7

Codes

  • NII Article ID (NAID)
    10008683660
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    4706225
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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