Stimulatory Effects of Centrally Injected Nitric Oxide Donors on Gastric Acid Secretion in Anesthetized Rats

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Author(s)

Abstract

The effects of centrally injected nitric oxide (NO) donors on gastric acid secretion were investigated in continuously perfused stomach of anesthetized rats. The lateral cerebroventricular (LV) injection of NOC5 (30 – 100 μg) and NOC12 (10 – 100 μg) dose-dependently stimulated gastric acid secretion. The LV injection of NOC18 (30 μg) also stimulated gastric acid secretion. The other type of NO donor, sodium nitroprusside (3 – 30 μg, LV), also dose-dependently stimulated gastric acid secretion. The effect of NOC5 at 100 μg was blocked by carboxy-PTIO, an NO scavenger, and by cervical vagotomy. Furthermore, NOC12 (30, 100 μg) dose-dependently stimulated gastric acid secretion in pylorus-ligated conscious rats. These results suggest that centrally injected NO donors stimulate gastric acid secretion in both conscious and anesthetized rats through vagus activation.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 89(2), 126-132, 2002-06-01

    The Japanese Pharmacological Society

References:  38

Codes

  • NII Article ID (NAID)
    10008683961
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    ART
  • ISSN
    00215198
  • NDL Article ID
    6261930
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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