Effects of Kampo Extracts on Drug Metabolism in Rat Liver Microsomes: Rhei Rhizoma Extract and Glycyrrhizae Radix Extract Inhibit Drug Oxidation

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Author(s)

Abstract

In the present study, the effects on drug oxidations in rat liver microsomes in vitro using 126 <i>Kampo</i> extracts were investigated. Although the effects of inhibition on drug oxidations were dependent on the <i>Kampo</i> extracts and probe reactions studied, most of the <i>Kampo</i> extracts showed inhibitory effects on both <i>N</i>-demethylations of aminopyrine and erythromycin in rat liver microsomes. Among the <i>Kampo</i> extracts studied herein, <i>Daio-kanzo-to</i> exhibited the most remarkable inhibitory effect on both reactions. The <i>Rhei Rhizoma</i> extract inhibited not only aminopyrine and erythromycin <i>N</i>-demethylations, but also phenacetin <i>O</i>-deethylation, 7-ethoxycoumarin <i>O</i>-deethylation, ethanol oxidation and tolbutamide 4-hydroxylation in rat liver microsomes. The <i>Glycyrrhizae Radix</i> extract also showed a remarkable inhibitory effect on phenacetin <i>O</i>-deethylation as well as aminopyrine and erythromycin <i>N</i>-demethylations. In contrast, the <i>Glycyrrhizae Radix</i> extract virtually showed no effect on ethanol oxidation.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 89(2), 164-170, 2002-06-01

    The Japanese Pharmacological Society

References:  31

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008684129
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    6262036
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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