Inhaled Pinacidil, an ATP-Sensitive K+ Channel Opener, and Moguisteine Have Potent Antitussive Effects in Guinea Pigs.
-
- Morita Kayo
- Department of Pathophysiology & Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University
-
- Onodera Kenji
- Department of Dental Pharmacology, Okayama University Graduate School of Medicine and Dentistry
-
- Kamei Junzo
- Department of Pathophysiology & Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University
この論文をさがす
抄録
We investigated whether inhaled pinacidil and moguisteine inhibit capsaicin-induced coughs in guinea pigs. Inhaled pinacidil (15 – 60 μg/ml), an ATP-sensitive K+ channel opener, and moguisteine (15 – 60 μg/ml) each dose-dependently inhibited the number of capsaicin-induced coughs. The antitussive effects of pinacidil and moguisteine were significantly antagonized by pretreatment with glibenclamide (10 mg/kg, i.p.), an ATP-sensitive K+ channel blocker. However, pretreatment with naloxone methiodide (10 mg/kg, s.c.) had no significant effect on the antitussive effects of either pinacidil or moguisteine. On the other hand, inhaled dihydrocodeine (15 – 60 μg/ml) also dose-dependently suppressed the number of capsaicin-induced coughs. The antitussive effect of inhaled dihydrocodeine was significantly antagonized by pretreatment with naloxone methiodide (10 mg/kg, s.c.), but not by glibenclamide (10 mg/kg, i.p.). These results indicate that inhaled pinacidil and moguisteine both attenuate capsaicin-induced coughs. Pinacidil and moguisteine may exert their antitussive effects through the activation of ATP-sensitive K+ channels in the tracheobronchial tract. Furthermore, it is possible that ATP-sensitive K+ channels may be involved in the antitussive effects of peripherally acting non-narcotic antitussive drugs.
収録刊行物
-
- Jpn.J.Pharmacol.
-
Jpn.J.Pharmacol. 89 (2), 171-175, 2002
公益社団法人 日本薬理学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390282679262692992
-
- NII論文ID
- 10008684161
-
- NII書誌ID
- AA00691188
-
- COI
- 1:STN:280:DC%2BD38znsFOmsA%3D%3D
-
- ISSN
- 13473506
- 00215198
-
- NDL書誌ID
- 6262049
-
- PubMed
- 12120760
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可