Effect of Anti-CD14 Antibody on Experimental Periodontitis Induced by Porphyromonas gingivalis Lipopolysaccharide

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Author(s)

    • KOWASHI Yusuke
    • Department of Periodontology and Endodontology, School of Dentistry, Health Sciences University of Hokkaido
    • KIKUCHI Masanori
    • National Institute for Materials Science, Advanced Materials Laboratory, Bioceramics Research Group
    • SUETSUGU Yasushi
    • National Institute for Materials Science, Advanced Materials Laboratory, Bioceramics Research Group
    • TANAKA Junzo
    • National Institute for Materials Science, Advanced Materials Laboratory, Bioceramics Research Group

Abstract

The lipopolysaccharide (LPS) released by <i>Porphyromonas gingivalis</i>, a Gram-negative bacterium found in the periodontal pockets of patients with periodontitis, induces bone resorbing activity in vivo. We previously showed that a receptor for LPS on human gingival fibroblasts and gingival epithelial cells is CD14. In this study, we established a mouse model of experimental periodontitis by applying a <i>P. gingivalis</i> LPS solution to the buccal region of mice. <i>P. gingivalis</i> LPS-induced bone resorption and interleukin-6 production in the gingival tissues were significantly inhibited by pretreatment with anti-CD14 antibody for 5 weeks prior to LPS treatment. This result suggests that anti-CD14 antibody may be usable as a prototype for the development of drugs for the treatment of periodontal disease.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 89(2), 176-183, 2002-06-01

    The Japanese Pharmacological Society

References:  32

Codes

  • NII Article ID (NAID)
    10008684188
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    ART
  • ISSN
    00215198
  • NDL Article ID
    6262082
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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