Functional Study on Nitroxidergic Nerve in Isolated Dog Pulmonary Arteries and Veins

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Author(s)

Abstract

In dog pulmonary arterial and venous strips without endothelium under treatment with prazosin, nicotine induced relaxation that was abolished by <i>N</i><sup>G</sup>-nitro-<sc><font size = -2>L</font></sc>-arginine, hexamethonium and methylene blue. <sc><font size = -2>L</font></sc>-Arginine antagonized the <i>N</i><sup>G</sup>-nitro-<sc><font size = -2>L</font></sc>-arginine action. Neurogenic relaxations tended to be more evident in the vein. Nitric oxide (NO)-induced relaxations were greater in the veins than in the arteries. Concentrations of NO to induce the same magnitude of relaxation as that to nicotine were higher in the arteries. In conclusion, dog pulmonary arteries and veins are innervated by nitroxidergic (nitrergic) nerves, and NO is released by nerve stimulation with nicotine in a larger amount in the artery than the vein.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 89(2), 197-200, 2002-06-01

    The Japanese Pharmacological Society

References:  15

Codes

  • NII Article ID (NAID)
    10008684267
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    00215198
  • NDL Article ID
    6262170
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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