Fulminant Diabetes Mellitus Associated with Pregnancy: Case Reports and Literature Review

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Author(s)

    • INAGAKI Takeshi
    • Department of Aging Medicine and Geriatrics, Shinshu University School of Medicine
    • SUZUKI Naomi
    • Department of Aging Medicine and Geriatrics, Shinshu University School of Medicine
    • SUZUKI Satoru
    • Department of Aging Medicine and Geriatrics, Shinshu University School of Medicine
    • AIZAWA Toru
    • Department of Aging Medicine and Geriatrics, Shinshu University School of Medicine
    • HASHIZUME Kiyoshi
    • Department of Aging Medicine and Geriatrics, Shinshu University School of Medicine

Abstract

We report two cases of type 1 diabetes mellitus fulminantly developed as diabetic ketoacidosis (DKA) at 19 weeks of gestation and immediately after delivery. Development of type 1 diabetes around pregnancy is not rare, but its fulminant development is highly uncommon. We also review the relevant literature concerning mostly Japanese cases. In our cases, the group of patients with fulminant progressive diabetes mellitus associated with pregnancy required insulin replacement therapy even after the acute period and showed high value of pancreatic exocrine enzymes, i.e. amylase, elastase, and lipase. The phenotype of this group was similar to “nonautoimmune, fulminant type 1 diabetes” described by Imagawa <i>et al</i>., where the laboratory data of type 1 diabetes-related autoantibodies showed negative. It is well known that autoimmune diseases are in good control during pregnancy. Our present finding suggests that this type of fulminant type 1 diabetes mellitus associated with pregnancy might develop as a consequence of a nonautoimmune mechanism.

Journal

  • Endocrine Journal

    Endocrine Journal 49(3), 319-322, 2002-06-01

    The Japan Endocrine Society

References:  14

Cited by:  3

Codes

  • NII Article ID (NAID)
    10008701492
  • NII NACSIS-CAT ID (NCID)
    AA10901436
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    09188959
  • Data Source
    CJP  CJPref  J-STAGE 
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