Prevalence of Serum Anti-Myeloperoxidase Antineutrophil Cytoplasmic Antibodies (MPO-ANCA) in Patients with Graves' Disease Treated with Propyithiouracil and Thiamazole

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Author(s)

    • WADA Norio
    • Division of Endocrinology and Metabolism, Department of Medicine, Sapporo City General Hospital
    • MUKAI Masaya
    • Division of Immunology and Hematology, Department of Medicine, Sapporo City General Hospital
    • KOHNO Michifumi
    • Division of Immunology and Hematology, Department of Medicine, Sapporo City General Hospital
    • NOTOYA Atsushi
    • Division of Immunology and Hematology, Department of Medicine, Sapporo City General Hospital
    • ITO Tomohiro
    • Division of Endocrinology and Metabolism, Department of Medicine, Sapporo City General Hospital
    • YOSHIOKA Narihito
    • Division of Endocrinology and Metabolism, Department of Medicine, Sapporo City General Hospital

Abstract

Patients with Graves' disease (n=61) treated wth propylthiouracil (PTU) or thiamazole (MMI) were studied retrospectively to investigate differences in the prevalence of anti-myeloperoxidase anti-neutrophil cytoplasmic antibodies (MPO-ANCA) in relation to treatment with anti-thyroid drugs. The patients were divided into two groups: PTU-treated group (n=32) and MMI-treated group (n=29). There were no significant differences between the two groups in terms of age, gender distribution, or duration of treatment. In the PTU group, 8/32 (25%) patients were positive for MPO-ANCA, whereas in the MMI group, 1/29 (3.4%) patients were positive. There were no significant differences in age, duration, or dosage between the MPO-ANCA positive and negative patients. Most of the MPO-ANCA positive patients were asymptomatic, except for two patients in whom rheumatic arthritis or membranous glomerulonephritis developed. None of the MPO-ANCA positive patients were diagnosed as having classical ANCA-associated vasculitis. Thus, there is a high frequency of MPO-ANCA in patients with Graves' disease treated with PTU, compared with patients treated with MMI, although classical ANCA-associated vasculitis develops in only a few MPO-ANCA positive patients.

Journal

  • Endocrine Journal

    Endocrine Journal 49(3), 329-334, 2002-06-01

    The Japan Endocrine Society

References:  32

Cited by:  3

Codes

  • NII Article ID (NAID)
    10008701528
  • NII NACSIS-CAT ID (NCID)
    AA10901436
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    09188959
  • Data Source
    CJP  CJPref  J-STAGE 
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