Prevalence of Serum Anti-Myeloperoxidase Antineutrophil Cytoplasmic Antibodies (MPO-ANCA) in Patients with Graves' Disease Treated with Propylthiouracil and Thiamazole.

• WADA NORIO

  Division of Endocrinology and Metabolism, Department of Medicine, Sapporo City General Hospital

• MUKAI MASAYA

  Division of Immunology and Hematology, Department of Medicine, Sapporo City General Hospital

• KOHNO MICHIFUMI

  Division of Immunology and Hematology, Department of Medicine, Sapporo City General Hospital

• NOTOYA ATSUSHI

  Division of Immunology and Hematology, Department of Medicine, Sapporo City General Hospital

• ITO TOMOHIRO

  Division of Endocrinology and Metabolism, Department of Medicine, Sapporo City General Hospital

• YOSHIOKA NARIHITO

  Division of Endocrinology and Metabolism, Department of Medicine, Sapporo City General Hospital

抄録

Patients with Graves' disease (n=61) treated wth propylthiouracil (PTU) or thiamazole (MMI) were studied retrospectively to investigate differences in the prevalence of anti-myeloperoxidase anti-neutrophil cytoplasmic antibodies (MPO-ANCA) in relation to treatment with anti-thyroid drugs. The patients were divided into two groups: PTU-treated group (n=32) and MMI-treated group (n=29). There were no significant differences between the two groups in terms of age, gender distribution, or duration of treatment. In the PTU group, 8/32 (25%) patients were positive for MPO-ANCA, whereas in the MMI group, 1/29 (3.4%) patients were positive. There were no significant differences in age, duration, or dosage between the MPO-ANCA positive and negative patients. Most of the MPO-ANCA positive patients were asymptomatic, except for two patients in whom rheumatic arthritis or membranous glomerulonephritis developed. None of the MPO-ANCA positive patients were diagnosed as having classical ANCA-associated vasculitis. Thus, there is a high frequency of MPO-ANCA in patients with Graves' disease treated with PTU, compared with patients treated with MMI, although classical ANCA-associated vasculitis develops in only a few MPO-ANCA positive patients.

収録刊行物

• Endocrine Journal

  Endocrine Journal 49 (3), 329-334, 2002

  一般社団法人 日本内分泌学会

キーワード

• Propylthiouracil
• Anti-myeloperoxidase antineutrophil cytoplasmic antibody
• ANCA-associated vasculitis

詳細情報

• CRID: 1390282681276872576
• NII論文ID: 10008701528
• NII論文ID: 30041005605
• NII書誌ID: AA10901436
• DOI: 10.1507/endocrj.49.329
• COI: 1:CAS:528:DC%2BD38XntVerurg%3D
• ISSN: 13484540
• ISSN: 09188959
• ISSN: http://id.crossref.org/issn/09188959
• PubMed: 12201217
• Web Site: http://www.jstage.jst.go.jp/article/endocrj/49/3/49_3_329/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2002259726
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可