Clinical Study of 33 Children with Systemic Pneumococcal Infections
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- SATO Atsuo
- Department of Pediatrics, Yokohama Sakae Kyosai Hospital
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- KITAZAWA Katsuhiko
- Department of Pediatrics, Asahi General Hospital
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- HONDA Akihito
- Department of Pediatrics, Asahi General Hospital
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- MAEMOTO Tatsuo
- Department of Pediatrics, Asahi General Hospital
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- INAKAWA Naohiro
- Department of Pediatrics, Asahi General Hospital
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- SENDA Masayoshi
- Department of Pediatrics, Asahi General Hospital
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- KOBAYASHI Hiroyuki
- Department of Pediatrics, Asahi General Hospital
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- IBE Masaaki
- Department of Pediatrics, Yokohama City University School of Medicine
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- MORI Masaaki
- Department of Pediatrics, Yokohama City University School of Medicine
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- YOKOTA Shumpei
- Department of Pediatrics, Yokohama City University School of Medicine
Bibliographic Information
- Other Title
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- 小児全身性肺炎球菌感染症33例の臨床的検討
- ショウニ ゼンシンセイ ハイエン キュウキン カンセンショウ 33レイ ノ リンショウテキ ケントウ
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Abstract
We retrospectively analyzed 33 cases of children with systemic pneumococcal infections, 22 bacteremia and 11 meningitis, diagnosed and treated in Asahi General Hospital between 1985 and 1999. The median age at diagnosis was 15 months old and the incidence peaked in infants between 7 and 24 months of age (57.6%). Two cases showed low serum IgG2 levels. Fever was a common symptom in all cases and 13 (39.4%) presented convulsions. Meningitis [median age: 10 months] tended to occur, if not significant, in younger children than bacteremia [16 months]. All cases of meningitis were diagnosed 12 hours or later after the onset of fever, though 54.5% of the cases of bacteremia were diagnosed within 12 hours. The cases of meningitis showed statistically lower white blood cell counts [median: 9, 700/mm3] and higher CRP levels [median: 25.6 mg/dl] than those of bacteremia [23, 900/mm3 and 4.2mg/dl, respectively] at diagnosis. Although all cases of bacteremia were cured without any sequelae by antibiotic treatment, 3 cases (27.3%) of meningitis died and 4 (36.4%) developed severe neurological sequelae. Our findings suggest that the putative pathogenesis by which pneumococcal meningitis results from bacteremia and, taking in the account of the poor outcome of meningitis, may justify the early antibiotic intervention against pneumococcal bacteremia.
Journal
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- Kansenshogaku Zasshi
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Kansenshogaku Zasshi 75 (12), 1007-1013, 2001
The Japanese Association for Infectious Diseases
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Details 詳細情報について
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- CRID
- 1390282680026001536
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- NII Article ID
- 130004330942
- 10008704241
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- NII Book ID
- AN00047715
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- ISSN
- 1884569X
- 03875911
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- NDL BIB ID
- 6006420
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- PubMed
- 11806134
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed