視性訓練による視性平衡機能向上の研究(2) : NMDA受容体の役割  [in Japanese] Improvement of Optokinetic Reflexes by Optokinetic Training (2) : Role of NMDA Receptors  [in Japanese]

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Author(s)

    • 宮田 英雄 MIYATA Hideo
    • 岐阜大学医学部耳鼻咽喉科学教室 Department of Otorhinolaryngology, Gifu University School of Medicine
    • 伊藤 八次 ITO Yatsuji
    • 岐阜大学医学部耳鼻咽喉科学教室 Department of Otorhinolaryngology, Gifu University School of Medicine

Abstract

To evaluate the involvement of N-methyl-D-aspartic acid (NMDA) receptors in the optokinetic training (OKT)-induced improvement of optokinetic nystagmus (OKN), we examined the effect on the optokinetic reflex of MK-801 ((±)-5-metyl-10, 11-dihydro-5H-dibenzo [a, d] cyclohepten-5, 10-imine maleate). Experiments were performed on pigmented rabbits in which OKN had been improved by OKT for 12 days. When MK-801 was injected intramuscularly, OKN was blocked; this blockade was completely reversed within 72 hrs. At non-intoxic doses (0.05 and 0.1 mg/kg), this drug caused an in-crease in locomotor activity and a reduction of OKN. On the other hand, neither the postrotatory nystagmus (PRN) nor the electroencephalogram (EEG) of the cerebral neocortex and hippocampus was influenced by non-intoxic doses of MK-801. A similar effect was observed on both atropine-sensitive and atropine-resistant EEGs. These results indicate that MK-801-induced impairment of OKN is probably due to its inhibition of NMDA receptors in the oculomotor pathway, suggesting that the activation of this recep-tor may be involved in the improvement of OKN by OKT.

Journal

  • Equilibrium Research

    Equilibrium Research 54(3), 287-295, 1995-06-01

    Japan Society for Equilibrium Research

References:  25

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008707884
  • NII NACSIS-CAT ID (NCID)
    AN00001485
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    03855716
  • Data Source
    CJP  CJPref  J-STAGE 
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