中枢前庭代償への内在性グルココルチコイドの関与　前庭代償とグルココルチコイド

• 山中 敏彰

  奈良県立医科大学耳鼻咽喉科学教室

• 松永 喬

  奈良県立医科大学耳鼻咽喉科学教室

書誌事項

タイトル別名

• Effects of Endogenous Glucocorticoid on Vestibular Compensation.
• 前庭代償とグルココルチコイド

抄録

A behavioral study was performed to examine the effect of glucocorticoid agonist (dexamethasone) and glucocorticoid receptor antagonist (RU38486) on the vestibular compensation following unilateral labyrinthectomy in pigmented young rabbits. The frequency of spontaneous nystagmus and the angle of head deviation were both reduced markedly in the rabbits treated with 1 or 5 mg/kg intravenous dexamethasone compared with the controls treated with saline. In contrast, intramuscular RU38486 retarded improvement of the vestibular symptons. These results suggest that endogenous glucocorticoids contribute to the achievement of the vestibular compensation.

収録刊行物

• Ｅｑｕｉｌｉｂｒｉｕｍ　Ｒｅｓｅａｒｃｈ

  Ｅｑｕｉｌｉｂｒｉｕｍ　Ｒｅｓｅａｒｃｈ 54 (4), 354-358, 1995

  一般社団法人 日本めまい平衡医学会

キーワード

• steroids
• endogenous glucocorticoid
• vestibular compensation
• behavioral study

詳細情報

• CRID: 1390282679922129536
• NII論文ID: 10008708033
• NII書誌ID: AN00001485
• DOI: 10.3757/jser.54.354
• ISSN: 1882577X
• ISSN: 03855716
• Web Site: https://search.jamas.or.jp/link/ui/1996074026
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可